Expression of HuD protein is essential for initial phase of neuronal differentiation in rat pheochromocytoma PC12 cells.

@article{Dobashi1998ExpressionOH,
  title={Expression of HuD protein is essential for initial phase of neuronal differentiation in rat pheochromocytoma PC12 cells.},
  author={Yoh Dobashi and M Shoji and Yuka Wakata and Toru Kameya},
  journal={Biochemical and biophysical research communications},
  year={1998},
  volume={244 1},
  pages={226-9}
}
HuD is a neuronal-specific, RNA-binding protein. Here we examined the change in the expression of HuD protein during nerve growth factor-mediated differentiation of PC12 cells. As cells differentiated and extended neurites, expression of HuD gradually increased up to 1.5-fold. When HuD expression was counteracted by antisense oligonucleotide, neurite extension was completely inhibited, yet the morphology of differentiated cells remained unchanged even after that treatment. Furthermore, this… CONTINUE READING

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