Expression of Hedgehog Pathway Mediator GLI Represents a Negative Prognostic Marker in Human Acute Myeloid Leukemia and Its Inhibition Exerts Antileukemic Effects.

@article{Wellbrock2015ExpressionOH,
  title={Expression of Hedgehog Pathway Mediator GLI Represents a Negative Prognostic Marker in Human Acute Myeloid Leukemia and Its Inhibition Exerts Antileukemic Effects.},
  author={Jasmin Wellbrock and Emily Latuske and Julian K{\"o}hler and Katharina Wagner and Hauke Stamm and Eik Vettorazzi and Gabi Vohwinkel and Marianne Klokow and Roswitha Uibeleisen and Patrick Ehm and Kristoffer Riecken and Sonja Loges and Felicitas R Thol and Claudia Schubert and Michael Amling and Manfred J{\"u}cker and C Carsten Bokemeyer and Michael Heuser and J{\"u}rgen G E Krauter and Walter Fiedler},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2015},
  volume={21 10},
  pages={2388-98}
}
PURPOSE The Hedgehog pathway plays an important role in stem-cell biology and malignant transformation. Therefore, we investigated the expression and prognostic impact of Hedgehog pathway members in acute myeloid leukemia (AML). EXPERIMENTAL DESIGN Pretreatment samples from 104 newly diagnosed AML patients (AMLSG 07-04 trial) were analyzed by qPCR, and expression of Hedgehog family members was correlated with clinical outcome. Inhibition of GLI by GANT61 or shRNA was investigated in AML cells… CONTINUE READING

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References

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Showing 1-10 of 51 references

All-trans retinoic acid improves outcome in younger adult patients with nucleophosmin-1 mutated acute myeloid leukemia—results of the AMLSG 07–04 randomized treatment trial

  • RF Schlenk, K D€ ohner, J Krauter, VI Gaidzik, P Paschka, M Heuser
  • Proceedings of the 53rd ASH Annual Meeting and…
  • 2011
Highly Influential
3 Excerpts

HemaExplorer: aWeb server for easy and fast visualization GLI Is a Negative Prognostic Marker in AML www.aacrjournals.org Clin Cancer Res

  • FO Bagger, N Rapin, K Theilgaard-Monch, B Kaczkowski, J Jendholm, WintherO
  • on October
  • 2015
1 Excerpt

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