Expression of HSP27, HSP72 and MRP proteins in in vitro co-culture of colon tumour cell spheroids with normal cells after incubation with rhTGF-β1 and/or CPT-11

@article{Paduch2009ExpressionOH,
  title={Expression of HSP27, HSP72 and MRP proteins in in vitro co-culture of colon tumour cell spheroids with normal cells after incubation with rhTGF-β1 and/or CPT-11},
  author={Roman Paduch and Joanna Jakubowicz-Gil and Martyna Kandefer-Szerszeń},
  journal={Journal of Biosciences},
  year={2009},
  volume={34},
  pages={927-940}
}
We studied the expression of inducible heat shock protein (HSP27, HSP72) and multidrug-resistance protein (MRP) in co-cultures of human colon carcinoma cell spheroids obtained from different grades of tumour with normal human colon epithelium, myofibroblast and endothelial cell monolayers. We also measured the influence of recombinant human transforming growth factor β1 (rhTGF-β1) and camptothecin (CPT-11), added as single agents or in combination, on the levels of the HSPs, MRP, interleukin… CONTINUE READING

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