Expression of HOX11 in childhood T-lineage acute lymphoblastic leukaemia can occur in the absence of cytogenetic aberration at 10q24: a study from the Children's Cancer Group (CCG)

@article{Kees2003ExpressionOH,
  title={Expression of HOX11 in childhood T-lineage acute lymphoblastic leukaemia can occur in the absence of cytogenetic aberration at 10q24: a study from the Children's Cancer Group (CCG)},
  author={Ursula R. Kees and N A Heerema and Rajiv Kumar and Paul M. Watt and David L. Baker and Mei K L La and Fatih M. Uckun and Harland N. Sather},
  journal={Leukemia},
  year={2003},
  volume={17},
  pages={887-893}
}
Clonal genetic aberrations in tumour cells provide critical information for the development of new diagnostic and therapeutic strategies for patients. In paediatric T-cell acute lymphoblastic leukaemia (T-ALL) chromosomal translocations are present in 30–35% of cases. HOX11 and the closely related HOX11L2 genes play a key role in T-ALL. HOX11 is aberrantly activated by either of the two chromosomal translocations, t(7;10) and t(10;14). In this study, HOX11 expression levels were measured by… CONTINUE READING

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