Expression of HNF4α isoforms in mouse liver development is regulated by sequential promoter usage and constitutive 3′ end splicing

@article{TorresPadilla2001ExpressionOH,
  title={Expression of HNF4α isoforms in mouse liver development is regulated by sequential promoter usage and constitutive 3′ end splicing},
  author={Maria Elena Torres-Padilla and Catherine Foug{\`e}re-Deschatrette and Mary C. Weiss},
  journal={Mechanisms of Development},
  year={2001},
  volume={109},
  pages={183-193}
}
Hepatocyte nuclear factor 4alpha (HNF4alpha) is essential for the establishment and maintenance of liver-specific gene expression. The HNF4alpha gene codes for several isoforms whose developmental and physiological relevance has not yet been explored. HNF4alpha1 and HNF4alpha7 originate from different promoters, while alternative splicing in 3' leads to HNF4alpha2 and HNF4alpha8, respectively. HNF4alpha7/alpha8 were abundantly expressed in embryonic liver and fetal-like hepatoma cells… CONTINUE READING

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Identification of an enhancer element upstream of the mouse HNFa1 promoter which is activated by glucocorticoids and live-enriched transcription factors

  • A. Bailly, M. E. Tores-Padilla, A. P. Tinel, M. C. Weiss
  • Nucleic Acids Res
  • 2001
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