Expression of HLA class I and beta 2-microglobulin on human choriocarcinoma cell lines: induction of HLA class I by interferon-gamma.

@article{Kato1991ExpressionOH,
  title={Expression of HLA class I and beta 2-microglobulin on human choriocarcinoma cell lines: induction of HLA class I by interferon-gamma.},
  author={Masakatsu Kato and Kenji Ohashi and Fumitaka Saji and A Wakimoto and Osamu Tanizawa},
  journal={Placenta},
  year={1991},
  volume={12 3},
  pages={217-26}
}
The trophoblast cells which contact with maternal tissue express HLA class I either weakly or not at all. This phenomenon is beneficial for the protection of the fetus from immunological rejection by the mother. However, the mechanisms of reduced expression of HLA class I are unexplained. Therefore, we utilized choriocarcinoma cells to analyse the suppressive mechanisms to HLA class I expression in trophoblasts. In this paper we reported the heterogeneity of HLA class I expression in five… CONTINUE READING