Expression of HLA-DR and cytokine genes on interferon-gamma-stimulated human salivary gland cell line.

@article{Hamano1996ExpressionOH,
  title={Expression of HLA-DR and cytokine genes on interferon-gamma-stimulated human salivary gland cell line.},
  author={Hironori Hamano and Norio Haneji and Kumiko Yanagi and Naozumi Ishimaru and Yasuhiro Hayashi},
  journal={Pathobiology : journal of immunopathology, molecular and cellular biology},
  year={1996},
  volume={64 5},
  pages={
          255-61
        }
}
Stimulation of a cultured human salivary gland (HSG) cell line by interferon (IFN)-gamma leads to HLA-DR gene expression concomitant with inflammatory cytokine genes such as IL-1 beta, tumor necrosis factor (TNF)-alpha, and IL-6 in vitro. IFN-gamma-induced HLA-DR mRNA expression was clearly detected at 2 h after the stimulation, and thereafter its level of gene expression increased until day 7 on HSG cells by reverse transcriptase (RT)-PCR. Immunofluorescence analysis revealed that cytoplasmic… CONTINUE READING