Expression of HERV-Fc1, a human endogenous retrovirus, is increased in patients with active multiple sclerosis.

  title={Expression of HERV-Fc1, a human endogenous retrovirus, is increased in patients with active multiple sclerosis.},
  author={Magdalena Janina Laska and Tomasz Brudek and Kari Konstantin Nissen and Tove K. Christensen and Ann{\'e} M\oller-Larsen and Thor Petersen and Bj\orn A Nex\o},
  journal={Journal of virology},
  volume={86 7},
Multiple sclerosis (MS) is considered to be an autoimmune disease with an unknown cause and with immune system dysregulation. Among environmental factors, viruses are most often connected with the etiology of MS. Human endogenous retroviruses (HERVs) constitute 5 to 8% of human genomic DNA and have been detected as transcripts and proteins in the central nervous system (CNS) and peripheral blood, frequently in the context of neuroinflammation. HERV-Fc1, which belongs to the HERV-H/F family, has… CONTINUE READING
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