Expression of HER-2 and nuclear localization of HER-3 protein in canine mammary tumors: histopathological and immunohistochemical study.

@article{Kim2011ExpressionOH,
  title={Expression of HER-2 and nuclear localization of HER-3 protein in canine mammary tumors: histopathological and immunohistochemical study.},
  author={Jong-Hyuk Kim and K S Im and Nam Hyun Kim and Ji Young Yhee and W G Nho and J H Sur},
  journal={Veterinary journal},
  year={2011},
  volume={189 3},
  pages={318-22}
}
HER-2 and HER-3 are transmembrane receptor proteins that are considered to be important but poorly understood biomarkers in canine tumors. In this study, the expression and the localization of HER-2 and HER-3 were evaluated immunohistochemically in canine mammary tumors (n=64; 12 benign, 52 malignant). HER-2 overexpression was identified in 2/12 (16.7%) benign and in 18/51 (35.3%) malignant cases. HER-3 was expressed in a non-nuclear localization in 11/12 (91.7%) benign and 18/52 (34.6… CONTINUE READING
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