Expression of GlyCAM-1, an endothelial ligand for L-selectin, is affected by afferent lymphatic flow.

@article{Mebius1993ExpressionOG,
  title={Expression of GlyCAM-1, an endothelial ligand for L-selectin, is affected by afferent lymphatic flow.},
  author={Reina E Mebius and Donald Dowbenko and A Williams and Christopher Fennie and Laurence A. Lasky and Susan R. Watson},
  journal={Journal of immunology},
  year={1993},
  volume={151 12},
  pages={
          6769-76
        }
}
The interaction of naive, L-selectin-bearing lymphocytes with counterreceptors on the surface of high endothelial venules (HEV) is the initial step in the extravasation of these cells from the bloodstream into the peripheral lymph node. Recently, two sulfated glycoprotein ligands, 50 and 90 kDa, respectively, have been identified as ligands for L-selectin using an L-selectin-IgG chimera. cDNA cloning of one of these molecules, the 50-kDa sulfated glycoprotein (glycosylation-dependent cell… CONTINUE READING

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Lymphatic vessels in health and disease.

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