Expression of Galectin-3 in Normal and Malignant Thyroid Tissue by Quantitative PCR and Immunohistochemistry

@article{Feilchenfeldt2003ExpressionOG,
  title={Expression of Galectin-3 in Normal and Malignant Thyroid Tissue by Quantitative PCR and Immunohistochemistry},
  author={Jonas Feilchenfeldt and Martin Toetsch and S Sheu and John Robert and Anastase Spiliopoulos and Andreja Frilling and Kurt Werner Schmid and Christoph A. Meier},
  journal={Modern Pathology},
  year={2003},
  volume={16},
  pages={1117-1123}
}
Galectin-3 has been extensively studied as an immunohistochemical marker of thyroid malignancy, and a high diagnostic accuracy has been reported even for difficult pathological diagnoses, such as minimal invasive follicular carcinoma. We consequently hypothesized that the quantitative analysis of galectin-3 mRNA rather than the more observer-dependent immunohistological determination might enhance the diagnostic workup of ambiguous thyroid lesions. In the present study, we set out to validate… CONTINUE READING