Expression of GRP and its receptor in well-differentiated colon cancer cells correlates with the presence of focal adhesion kinase phosphorylated at tyrosines 397 and 407.

@article{Matkowskyj2003ExpressionOG,
  title={Expression of GRP and its receptor in well-differentiated colon cancer cells correlates with the presence of focal adhesion kinase phosphorylated at tyrosines 397 and 407.},
  author={Kristina A Matkowskyj and Kristin A Keller and Sarah C Glover and Lori Kornberg and Roger Tran-Son-Tay and Richard V. Benya},
  journal={The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society},
  year={2003},
  volume={51 8},
  pages={1041-8}
}
Gastrin-releasing peptide (GRP) and its receptor (GRP-R) are not normally expressed by epithelial cells lining the colon but are aberrantly expressed in cancer, where they act as morphogens and regulate tumor cell differentiation. Studies of colon cancer formation in mice genetically incapable of synthesizing GRP-R suggested that this receptor's morphogenic properties were mediated via focal adhesion kinase (FAK). We therefore set out to determine the presence of both total and phosphorylated… CONTINUE READING
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