Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells

@article{Wang2009ExpressionOG,
  title={Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells},
  author={R. Wang and L. Kozhaya and Frances Mercer and A. Khaitan and H. Fujii and D. Unutmaz},
  journal={Proceedings of the National Academy of Sciences},
  year={2009},
  volume={106},
  pages={13439 - 13444}
}
The molecules that define human regulatory T cells (Tregs) phenotypically and functionally remain to be fully characterized. We recently showed that activated human Tregs express mRNA for a transmembrane protein called glycoprotein A repetitions predominant (GARP, or LRRC32). Here, using a GARP-specific mAb, we demonstrate that expression of GARP on activated Tregs correlates with their suppressive capacity. However, GARP was not induced on T cells activated in the presence of TGFβ, which… Expand
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This information is current as Vivo T Cells In + Maintenance of Peripheral CD 4 andRegulate Regulatory T Cell Development Complexes Negatively β TGF-− GARP Unutmaz
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