Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells

@article{Wang2009ExpressionOG,
  title={Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells},
  author={R. Wang and L. Kozhaya and Frances Mercer and A. Khaitan and H. Fujii and D. Unutmaz},
  journal={Proceedings of the National Academy of Sciences},
  year={2009},
  volume={106},
  pages={13439 - 13444}
}
The molecules that define human regulatory T cells (Tregs) phenotypically and functionally remain to be fully characterized. We recently showed that activated human Tregs express mRNA for a transmembrane protein called glycoprotein A repetitions predominant (GARP, or LRRC32). Here, using a GARP-specific mAb, we demonstrate that expression of GARP on activated Tregs correlates with their suppressive capacity. However, GARP was not induced on T cells activated in the presence of TGFβ, which… Expand
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References

SHOWING 1-10 OF 28 REFERENCES
Identification of a Regulatory T Cell Specific Cell Surface Molecule that Mediates Suppressive Signals and Induces Foxp3 Expression
Naive Precursors of Human Regulatory T Cells Require FoxP3 for Suppression and Are Susceptible to HIV Infection1
Generation of potent and stable human CD4+ T regulatory cells by activation-independent expression of FOXP3.
Inducible reprogramming of human T cells into Treg cells by a conditionally active form of FOXP3
Identification of IL-17-producing FOXP3+ regulatory T cells in humans
CD4+FoxP3+ regulatory T cells confer infectious tolerance in a TGF-β–dependent manner
HIV Infection of Naturally Occurring and Genetically Reprogrammed Human Regulatory T-cells
In vivo expansion of CD4CD45RO-CD25 T cells expressing foxP3 in IL-2-treated HIV-infected patients.
...
1
2
3
...