Expression of Foxp3 in non-small cell lung cancer patients is significantly higher in tumor tissues than in normal tissues, especially in tumors smaller than 30 mm.

@article{Ishibashi2006ExpressionOF,
  title={Expression of Foxp3 in non-small cell lung cancer patients is significantly higher in tumor tissues than in normal tissues, especially in tumors smaller than 30 mm.},
  author={Yasunori Ishibashi and Shigebumi Tanaka and Kohei Tajima and Takeshi Yoshida and Hiroyuki Kuwano},
  journal={Oncology reports},
  year={2006},
  volume={15 5},
  pages={1315-9}
}
Active suppression by CD4+CD25+ T regulatory cells (T regs) plays an important role in the down-regulation of T cell responses to foreign and self-antigens. Thus far, the potential role of T regs in human tumors has been reported. T reg-mediated suppression of antitumor immune responses may partly explain the poor clinical response to vaccine-based immunotherapy for human cancer. The forkhead transcription factor Foxp3 is a critical regulator of T regs development and function. Foxp3 represents… CONTINUE READING