Expression of Fas ligand in newly diagnosed childhood acute lymphoblastic leukemia.

@article{Volm1999ExpressionOF,
  title={Expression of Fas ligand in newly diagnosed childhood acute lymphoblastic leukemia.},
  author={M. Volm and Felix Zintl and A. Sauerbrey and Reet Koom{\"a}gi},
  journal={Anticancer research},
  year={1999},
  volume={19 4C},
  pages={3399-402}
}
Immunocytochemistry was used to analyze the expression of the Fas ligand (FasL) in sixty-four children with newly diagnosed acute lymphoblastic leukemia (ALL). FasL expression was detected in 55 of 64 children (86%). Children with newly diagnosed ALL and FasL expression exhibited longer relapse-free and overall survival times under chemotherapy than did patients who did not express the Fas ligand. These data suggest that Fas/FasL mediated signaling may play a general role in the cytotoxicity of… CONTINUE READING