Expression of Fas and Fas ligand in uveal melanoma: biological implication and prognostic value.

@article{Anastassiou2001ExpressionOF,
  title={Expression of Fas and Fas ligand in uveal melanoma: biological implication and prognostic value.},
  author={Gerasimos Anastassiou and Sarah E Coupland and Axel Stang and R{\'e}ka Boeloeni and Harald Schilling and Norbert Bornfeld},
  journal={The Journal of pathology},
  year={2001},
  volume={194 4},
  pages={
          466-72
        }
}
The interaction between Fas and Fas ligand is one possible immune escape mechanism used by tumour cells. In the present study, melanoma tissue from 103 patients who underwent enucleation for malignant uveal melanoma (iris melanomas excluded) was stained by immunohistochemistry with monoclonal antibodies specific for Fas, Fas ligand, CD3, CD8, and CD68. Histological and clinical data for these tumours were assessed. Both Fas and Fas ligand were detected in uveal melanomas. Cells of the monocyte… CONTINUE READING
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