Expression of FOXC2 in adipose and muscle and its association with whole body insulin sensitivity.

@article{DiGregorio2004ExpressionOF,
  title={Expression of FOXC2 in adipose and muscle and its association with whole body insulin sensitivity.},
  author={Gina B Di Gregorio and Rickard Westergren and S. Enerback and Tong Lu and Philip A. Kern},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2004},
  volume={287 4},
  pages={
          E799-803
        }
}
FOXC2 is a winged helix/forkhead transcription factor involved in PKA signaling. Overexpression of FOXC2 in the adipose tissue of transgenic mice protected against diet-induced obesity and insulin resistance. We examined the expression of FOXC2 in fat and muscle of nondiabetic humans with varying obesity and insulin sensitivity. There was no relation between body mass index (BMI) and FOXC2 mRNA in either adipose or muscle. There was a strong inverse relation between adipose FOXC2 mRNA and… 
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Results Citations
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24 Citations

Citation Type

Citation Type

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Important roles of FOXC2 and FOXF2 in insulin sensitivity and kidney function are demonstrated, roles that might also be relevant to human disease conditions.
Hyperinsulinemia drives diet-induced obesity independently of brain insulin production.
Obesity and polymorphisms in genes regulating human adipose tissue
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A comprehensive review of adipose-tissue-expressed genes implicated in predisposition to human obesity is provided and it is predicted that additional alleles in genes regulating adipose tissue function will be established as risk factors for common obesity in the coming years.
Dietary obesity-induced Egr-1 in adipocytes facilitates energy storage via suppression of FOXC2
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An important role is suggested for Egr-1, which, by repressing FOXC2 expression, promotes energy storage in WAT and favored the development of obesity under high energy intake.
Overexpression of transcription factor FOXC2 in cultured human podocytes upregulates injury markers and increases motility.
α-MSH and Foxc2 promote fatty acid oxidation through C/EBPβ negative transcription in mice adipose tissue
TLDR
It is demonstrated that α-MSH and Foxc2 increased palmitate oxidation to CO2 in white (WAT) and brown adipose tissue (BAT) and inhibited FAO through cAMP/PKA pathway-specific inhibitor and C/EBPβ as a transcription suppressor inhibits α- MSH andFoxc2 expression and FAO.
Foxc2 Is a Common Mediator of Insulin and Transforming Growth Factor &bgr; Signaling to Regulate Plasminogen Activator Inhibitor Type I Gene Expression
TLDR
It is proposed that Foxc2 is a key molecule to regulate PAI-1 gene expression via 2 distinct target sites, an insulin response element (IRE) and a novel forkhead-binding element (FBE), adjacent to a Smad-binding site, which mediates insulin action competing with another Forkhead protein, FOXO1, via the insulin responseelement.
Metabolic consequences of lipodystrophy in mouse models
  • K. Reue, J. Phan
  • Biology
    Current opinion in clinical nutrition and metabolic care
  • 2006
TLDR
Reductions in the capacity of adipose tissue to store triglycerides or to secrete adipokine hormones lead to altered lipid metabolism and insulin resistance, and enhanced energy metabolism cannot overcome the deleterious effects of impaired adipokines production, as revealed by studies of models with both lipoatrophic and energetic effects.
Chapter 7 FOXC2 in the adipocyte
Plasminogen activator inhibitor-1, adipose tissue and insulin resistance
TLDR
PAI-1 is an attractive new therapeutic target to retard the metabolic complications that accompany obesity, and its involvement in controlling the biology of adipose tissue is emphasized.
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