Expression of FACT in mammalian tissues suggests its role in maintaining of undifferentiated state of cells

@inproceedings{Garcia2011ExpressionOF,
  title={Expression of FACT in mammalian tissues suggests its role in maintaining of undifferentiated state of cells},
  author={Henry Garcia and Daria I Fleyshman and Katerina Kolesnikova and Alfiya F Safina and Mairead Commane and Geraldine M. Paszkiewicz and Angela Omelian and Carl D. Morrison and Kateryna Gurova},
  booktitle={Oncotarget},
  year={2011}
}
The Facilitates Chromatin Transcription (FACT) chromatin remodeling complex, comprised of two subunits, SSRP1 and SPT16, is involved in transcription, replication and DNA repair. We recently showed that curaxins, small molecules with anti-cancer activity, target FACT and kill tumor cells in a FACT-dependent manner. We also found that FACT is overexpressed in human and mouse tumors and that tumor cells are sensitive to FACT downregulation. To clarify the clinical potential of FACT inhibition, we… CONTINUE READING

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