Expression of EZH2 in renal cell carcinoma as a novel prognostic marker.

  title={Expression of EZH2 in renal cell carcinoma as a novel prognostic marker.},
  author={Hye Won Lee and Misun Choe},
  journal={Pathology international},
  volume={62 11},
Enhancer of zeste homolog 2 (EZH2) is a member of the Polycomb group proteins and a part of Polycomb repressive complex 2. EZH2 is important for transcriptional regulation through nucleosome modification and interaction with other transcription factors. Particularly, aberration of EZH2 has been implicated in oncogenesis and progression of various neoplasms. The objective of this study was to evaluate EZH2 expression in renal cell carcinoma (RCC), especially clear cell RCC (CRCC) and correlate… CONTINUE READING
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