Expression of ER stress markers (GRP78/BiP and PERK) in adenoid cystic carcinoma.

  title={Expression of ER stress markers (GRP78/BiP and PERK) in adenoid cystic carcinoma.},
  author={Kyoichi Kaira and Minoru Toyoda and Akira Shimizu and Masato Shino and Koichi Sakakura and Yukihiro Takayasu and Katsumasa Takahashi and Takayuki Asao and Kazuaki Chikamatsu},
  journal={Acta oto-laryngologica},
  volume={136 1},
CONCLUSION A high GRP78/BiP expression was proved to be a significant marker for predicting poor outcome after surgery. GRP78/BiP may be a promising molecular target for treatment of ACC. BACKGROUND The glucose-regulated protein GRP78/BiP plays a crucial role in the endoplasmic reticulum (ER) stress. The level of GRP78 is highly elevated in various human cancers, but the clinicopathological significance of GRP78/BiP remains controversial in patients with adenoid cystic carcinoma (ACC… CONTINUE READING