Expression of EBNA-1 mRNA is regulated by cell cycle during Epstein-Barr virus type I latency.

@article{Davenport1999ExpressionOE,
  title={Expression of EBNA-1 mRNA is regulated by cell cycle during Epstein-Barr virus type I latency.},
  author={Matthew G Davenport and Joseph Stephen Pagano},
  journal={Journal of virology},
  year={1999},
  volume={73 4},
  pages={3154-61}
}
Expression of EBNA-1 protein is required for the establishment and maintenance of the Epstein-Barr virus (EBV) genome during latent infection. During type I latency, the BamHI Q promoter (Qp) gives rise to EBNA-1 expression. The dominant regulatory mechanism for Qp appears to be mediated through the Q locus, located immediately downstream of the transcription start site. Binding of EBNA-1 to the Q locus represses Qp constitutive activity, and repression has been reported to be overcome by an… CONTINUE READING

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