Expression of EAAT1 reflects a possible neuroprotective function of reactive astrocytes and activated microglia following human traumatic brain injury.

@article{Beschorner2007ExpressionOE,
  title={Expression of EAAT1 reflects a possible neuroprotective function of reactive astrocytes and activated microglia following human traumatic brain injury.},
  author={Rudi Beschorner and Katharina Dietz and Nathalie Schauer and Michel Mittelbronn and Hermann Josef Schluesener and Karolin Trautmann and Richard Meyermann and Perikles Simon},
  journal={Histology and histopathology},
  year={2007},
  volume={22 5},
  pages={
          515-26
        }
}
UNLABELLED Glutamate-mediated excitotoxicity is known to cause secondary brain damage following stroke and traumatic brain injury (TBI). However, clinical trials using NMDA antagonists failed. Thus, glial excitatory amino acid transporters (EAATs) might be a promising target for therapeutic intervention. METHODS AND RESULTS We examined expression of EAAT1 (GLAST) and EAAT2 (Glt-1) in 36 TBI cases by immunohistochemistry. Cortical expression of both EAATs decreased rapidly and widespread… CONTINUE READING
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