Expression of E6/E7 or SV40 large T antigen-coding oncogenes in human corneal endothelial cells indicates regulated high-proliferative capacity.

@article{Wilson1995ExpressionOE,
  title={Expression of E6/E7 or SV40 large T antigen-coding oncogenes in human corneal endothelial cells indicates regulated high-proliferative capacity.},
  author={Steven E. Wilson and Jinsheng Weng and Seth Blair and Yu Guang He and S. A. Lloyd},
  journal={Investigative ophthalmology & visual science},
  year={1995},
  volume={36 1},
  pages={32-40}
}
PURPOSE Human corneal endothelial cells are thought to have limited capacity for proliferation. Little is known about the mechanisms that regulate the proliferation of these cells. The authors introduced oncogenes into human corneal endothelial cells to modulate proliferation. In addition, they sought to establish cell lines to facilitate study of human corneal endothelial cells. METHODS Early-passage human corneal endothelial cells were transduced with disabled retrovirus (pLXSN16E6/E7… CONTINUE READING