Expression of E-cadherin repressors SNAIL, ZEB1 and ZEB2 by tumour and stromal cells influences tumour-budding phenotype and suggests heterogeneity of stromal cells in pancreatic cancer

@inproceedings{Galvn2015ExpressionOE,
  title={Expression of E-cadherin repressors SNAIL, ZEB1 and ZEB2 by tumour and stromal cells influences tumour-budding phenotype and suggests heterogeneity of stromal cells in pancreatic cancer},
  author={Jos{\'e} Alberto Galv{\'a}n and Inti Zlobec and Martin Wartenberg and Alessandro Lugli and Beat Gloor and Aurel Perren and Eva Karamitopoulou},
  booktitle={British Journal of Cancer},
  year={2015}
}
Background:There is evidence that tumour–stroma interactions have a major role in the neoplastic progression of pancreatic ductal adenocarcinoma (PDAC). Tumour budding is thought to reflect the process of epithelial–mesenchymal transition (EMT); however, the relationship between tumour buds and EMT remains unclear. Here we characterize the tumour-budding- and stromal cells in PDAC at protein and mRNA levels concerning factors involved in EMT.Methods:mRNA in situ hybridisation and immunostaining… CONTINUE READING
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Surgery in the treatment of exocrine pancreas and prognosis

  • C Fernandez-del-Castillo, RE Jimenez, ML Steer
  • Editor: Tanabe KK. www.uptodate.com
  • 2013
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