Expression of E-cadherin is associated with squamous differentiation in squamous cell carcinomas.

@article{Wu2000ExpressionOE,
  title={Expression of E-cadherin is associated with squamous differentiation in squamous cell carcinomas.},
  author={Hillary H Wu and Reuben Lotan and David G. Menter and Scott Michael Lippman and X{\`i}ao-chun Xu},
  journal={Anticancer research},
  year={2000},
  volume={20 3A},
  pages={1385-90}
}
E-cadherin is a cell surface molecule that mediates cell-cell adhesion in normal epithelium. Disabled or aberrant E-cadherin expression increases cell motility and promotes the transition of well-differentiated adenoma to invasive carcinoma. To evaluate whether E-cadherin could serve as a biomarker of squamous cell differentiation, we analyzed its expression by immunohistochemistry in formalin-fixed, paraffin-embedded tissue sections of 7 head and neck cancer patients, 19 lung cancer patients… CONTINUE READING

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