Expression of E‐SOD, GPX5 mRNAs and immunoexpression of Cu/ZnSOD in epididymal epithelial cells of finasteride‐treated rats

  title={Expression of E‐SOD, GPX5 mRNAs and immunoexpression of Cu/ZnSOD in epididymal epithelial cells of finasteride‐treated rats},
  author={A. Kolasa and M. Marchlewicz and G. Adler and A. Ciechanowicz and W. Głąbowski and B. Wiszniewska},
  • A. Kolasa, M. Marchlewicz, +3 authors B. Wiszniewska
  • Published 2008
  • Biology, Medicine
  • Andrologia
  • We studied the immunoexpression of Cu/Zn superoxide dismutase (Cu/ZnSOD) and mRNAs expression of extracellular superoxide dismutase (E‐SOD), and epididymal specific glutathione peroxidase 5 (GPX5), in epithelial cells of caput and cauda epididymis of rats treated with finasteride, a steroid‐based inhibitor of 5α‐reductase. The 5α‐reductase is known to exist in two isoforms. Both 5α‐red1 and 5α‐red2 catalyse the irreversible conversion of T into DHT. Formation of DHT in the epididymis is mostly… CONTINUE READING
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