Corpus ID: 90100523

Expression of Drop1, a gene encoding a 350 kDa protein, is downregulated in epithelial malignancies

@article{Marm2004ExpressionOD,
  title={Expression of Drop1, a gene encoding a 350 kDa protein, is downregulated in epithelial malignancies},
  author={A. Marm{\'e} and H. Zimmermann and G. Moldenhauer and M. Schorpp-Kistner and C. Dallner and M. Lindner and A. Koppe and J. Kretschmer and B. Seib and E. Spiess and G. Bastert and D. Wallwiener and H. Ponstingl},
  journal={Cancer Research},
  year={2004},
  volume={64},
  pages={626-626}
}
  • A. Marmé, H. Zimmermann, +10 authors H. Ponstingl
  • Published 2004
  • Biology
  • Cancer Research
  • 2713 In a study employing differential display analysis to identify differentially expressed genes in ovarian carcinomas, we found an 11 kb mRNA coding for a 350 kDa Protein suppressed in over 70% of ovarian and mammary carcinomas. Its expression is downregulated 20-1000 fold in these tumors. cDNA arrays of matched pairs of tumor and normal tissue showed that the mRNA of Drop 1 is downregulated in more than 80% of epithelial tumors, such as ovary (>80%), breast (>50%), kidney (>90%), lung (>70… CONTINUE READING