Expression of Dickkopf genes is strongly reduced in malignant melanoma

@article{Kuphal2006ExpressionOD,
  title={Expression of Dickkopf genes is strongly reduced in malignant melanoma},
  author={Silke Kuphal and Sibylla Lodermeyer and Frauke Bataille and Marion M Schuierer and Bang H. Hoang and Anja Katrin Bosserhoff},
  journal={Oncogene},
  year={2006},
  volume={25},
  pages={5027-5036}
}
The Dickkopf (DKK) genes were originally identified as factors inducing head formation in Xenopus. The genes code for inhibitors that are involved in Wnt signaling. We speculate that loss of DKK expression plays a role in development or progression of malignant melanoma. Thus, we evaluated melanoma cell lines and tissue samples of malignant melanoma for… CONTINUE READING