Expression of DC-SIGN by dendritic cells of intestinal and genital mucosae in humans and rhesus macaques.

@article{Jameson2002ExpressionOD,
  title={Expression of DC-SIGN by dendritic cells of intestinal and genital mucosae in humans and rhesus macaques.},
  author={Brian Jameson and Fr{\'e}d{\'e}ric Baribaud and Stefan P{\"o}hlmann and Darlene Ghavimi and Frank Mortari and Robert W. Doms and Akiko Iwasaki},
  journal={Journal of virology},
  year={2002},
  volume={76 4},
  pages={1866-75}
}
To better understand the role of dendritic cells (DCs) in human immunodeficiency virus (HIV) transmission at mucosal surfaces, we examined the expressions of the HIV adhesion molecule, dendritic-cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN), its closely related homologue DC-SIGNR, and HIV coreceptors by distinct DC populations in the intestinal and genital tracts of humans and rhesus macaques. We also developed monoclonal antibodies (MAbs) specific for DC-SIGN or DC-SIGNR. In the Peyer's… CONTINUE READING
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