Expression of Coxsackie adenovirus receptor and alphav-integrin does not correlate with adenovector targeting in vivo indicating anatomical vector barriers

Abstract

Recombinant adenoviral vectors are broadly applied in gene therapy protocols. However, adenovector-mediated gene transfer has limitations in vivo. One of these is the low gene transfer rate into organs other than the liver after systemic intravenous vector injection. Local direct injection into the target organ has been used as one possible solution, but… (More)
DOI: 10.1038/sj.gt.3301030

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Cite this paper

@article{Fechner1999ExpressionOC, title={Expression of Coxsackie adenovirus receptor and alphav-integrin does not correlate with adenovector targeting in vivo indicating anatomical vector barriers}, author={H. Fechner and Alina Haack and H Wang and X. Wang and Karin Eizema and Matthias Pauschinger and Robin Schoemaker and Richard van Veghel and Adriaan B. Houtsmuller and Heinz Peter Schultheiss and Jos M. J. Lamers and W. Poller}, journal={Gene Therapy}, year={1999}, volume={6}, pages={1520-1535} }