Expression of Cdx1 and Cdx2 mRNAs and relevance of this expression to differentiation in human gastrointestinal mucosa — with special emphasis on participation in intestinal metaplasia of the human stomach

@article{Mizoshita2001ExpressionOC,
  title={Expression of Cdx1 and Cdx2 mRNAs and relevance of this expression to differentiation in human gastrointestinal mucosa — with special emphasis on participation in intestinal metaplasia of the human stomach},
  author={Tsutomu Mizoshita and Ken-ichi Inada and Tetsuya Tsukamoto and Yasuhiro Kodera and Yoshitaka Yamamura and Takashi Hirai and Tomoyuki Kato and Takashi Joh and Makoto Itoh and Masae Tatematsu},
  journal={Gastric Cancer},
  year={2001},
  volume={4},
  pages={185-191}
}
Background. The caudal-type homeobox genes, Cdx1 and Cdx2, are candidates for directing intestinal development, differentiation, and maintenance of the intestinal phenotype. The aims of this study were: (1) to assess the normal tissue expression patterns of Cdx1 and Cdx2 in the human gastrointestinal tract and (2) to ascertain levels in intestinal metaplasia (IM) of the stomach associated with gastritis. Methods. Fresh human tissues were collected by surgical resection from 39 patients after… CONTINUE READING

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