Expression of Cathepsin L in tumor cells and tumor-associated macrophages in patients with Ewing sarcoma family of tumors: a pilot study.

@article{Biswas2015ExpressionOC,
  title={Expression of Cathepsin L in tumor cells and tumor-associated macrophages in patients with Ewing sarcoma family of tumors: a pilot study.},
  author={Bivas Biswas and Mehar Chand Sharma and Asit Ranjan Mridha and Sameer Bakhshi},
  journal={Indian journal of pathology & microbiology},
  year={2015},
  volume={58 2},
  pages={170-4}
}
BACKGROUND Cysteine protease Cathepsin L is involved in bone remodeling and expressed in activated macrophages. It is highly expressed in metastatic tumor tissue, especially with bone metastases. AIMS We evaluated immunohistochemical expression of Cathepsin L in tumor cells and tumor-associated macrophages (TAMs) in chemo-naive Ewing sarcoma. SETTINGS AND DESIGN Retrospective evaluation of archived specimens of Ewing sarcoma. MATERIALS AND METHODS Immunohistochemical staining was… CONTINUE READING