Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.

@article{Drocourt2002ExpressionOC,
  title={Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.},
  author={Lionel Drocourt and Jean-Claude Ourlin and Jean Marc Pascussi and Patrick Maurel and M. C. Vilarem},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 28},
  pages={25125-32}
}
The fully active dihydroxylated metabolite of vitamin D(3) induces the expression of CYP3A4 and, to a lesser extent, CYP2B6 and CYP2C9 genes in normal differentiated primary human hepatocytes. Electrophoretic mobility shift assays and cotransfection in HepG2 cells using wild-type and mutated oligonucleotides revealed that the vitamin D receptor (VDR) binds and transactivates those xenobiotic-responsive elements (ER6, DR3, and DR4) previously identified in CYP3A4, CYP2B6, and CYP2C9 promoters… CONTINUE READING
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