Expression of CXCL12 and CXCR4 in pT3-stage gastric cancer does not correlate with peritoneal metastasis.

  title={Expression of CXCL12 and CXCR4 in pT3-stage gastric cancer does not correlate with peritoneal metastasis.},
  author={Kenji Tsuboi and Yasuhiro Kodera and Hayao Nakanishi and Seiji Ito and Yoshinari Mochizuki and Goro Nakayama and Masahiko Koike and Michitaka Fujiwara and Yoshitaka Yamamura and Akimasa Nakao},
  journal={Oncology reports},
  volume={20 5},
CXCR4, a chemokine receptor, is considered to be involved in the metastastic formation of various types of cancer and could influence survival. More recently, CXCR4 was reported to be associated with peritoneal metastasis in gastric cancer, and CXCL12, its ligand, as a prognostic determinant among gastric cancer of various stages. In order to more specifically delineate the relevance of CXCR4 in peritoneal metastasis, 98 patients with pT3-stage gastric cancer who underwent gastrectomy and… CONTINUE READING


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