Expression of CK19 in invasive breast carcinomas of special histological types: implications for the use of one-step nucleic acid amplification.

@article{Alvarenga2011ExpressionOC,
  title={Expression of CK19 in invasive breast carcinomas of special histological types: implications for the use of one-step nucleic acid amplification.},
  author={C{\'e}sar Augusto Alvarenga and Paula Itagyba Paravidino and Marcelo Alvarenga and Rozany Mucha Dufloth and M. Salom{\'e} Gomes and Luiz Carlos Zeferino and F Schmitt},
  journal={Journal of clinical pathology},
  year={2011},
  volume={64 6},
  pages={493-7}
}
BACKGROUND The sentinel lymph node (SLN) is the first lymph node to receive the lymphatic drainage of a primary tumour; based on the knowledge that CK19 is positive in more than 95% of breast carcinomas, a molecular method for intraoperative diagnosis of SLN metastases (the one-step nucleic acid amplification (OSNA) assay) was developed. AIMS To evaluate CK19 immunoreactivity in a series of special histological types of breast carcinoma in order to verify whether the OSNA assay can be used in… CONTINUE READING

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