Expression of CDX2 in normal and neoplastic human colon tissue and during differentiation of an in vitro model system.

@article{Qualtrough2002ExpressionOC,
  title={Expression of CDX2 in normal and neoplastic human colon tissue and during differentiation of an in vitro model system.},
  author={David Qualtrough and Takao Hinoi and Eric R. Fearon and Chris Paraskeva},
  journal={Gut},
  year={2002},
  volume={51 2},
  pages={184-90}
}
BACKGROUND The Cdx genes are expressed in the colorectal epithelium and are frequently downregulated during tumorigenesis. Overexpression of Cdx genes has been shown previously to result in cellular differentiation. AIM To study expression of CDX2 in normal and neoplastic human colon using a newly isolated monoclonal antibody. To define expression of CDX1 and CDX2 in an in vitro model system of colorectal tumour progression and to ascertain whether these are subject to regulation during… CONTINUE READING