Expression of CD95 (Fas) in sun‐exposed human skin and cutaneous carcinomas

@article{Filipowicz2002ExpressionOC,
  title={Expression of CD95 (Fas) in sun‐exposed human skin and cutaneous carcinomas},
  author={Ewa A. Filipowicz and Patrick A. Adegboyega and RAMON L. Sanchez and Zoran Gatalica},
  journal={Cancer},
  year={2002},
  volume={94}
}
Carcinomas of the skin are by far the most common human malignancies. Continuous exposure to ultraviolet (UV) light facilitates the development of precancerous lesions (actinic keratosis [AK]) that may progress to invasive squamous carcinomas. Apoptosis, triggered by the activation of CD95 (Fas), is one of the most important defense mechanisms against UV light–induced carcinogenesis in experimental models, but the dynamics of CD95 expression in patients with sun‐induced lesions are largely… 
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TLDR
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TLDR
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TLDR
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TLDR
It is reported here that chronic oral administration of cyclopamine dramatically reduces (∼66%) UVBinduced basal cell carcinoma formation in Ptch1+/− mice, and that a major mechanism of their inhibitory effect is through up-regulation of Fas, which augments apoptosis.
Apoptosis in Human Skin: Role in Pathogenesis of Various Diseases and Relevance for Therapy
TLDR
The different forms of cell death in the skin are reviewed and the role of apoptosis in diseases like skin cancer, psoriasis, and systemic lupus erythematosus is discussed.
Premature keratinocyte death and expression of marker proteins of apoptosis in human skin after UVB exposure
TLDR
Morphometric evaluation of the immunohistochemical data demonstrated that maximal upregulation of P53, DNase I and activation of caspase-3 occurred 12 h after irradiation and in advance of the peak of apoptotic cell death reached after 24 h as verified by ISEL.
Pathology and pathobiology of actinic (solar) keratosis – an update
TLDR
Actinic keratosis is a UV light‐induced lesion and develops mostly in fair‐skinned patients being susceptible to solar damage and is considered as an early in situ squamous cell carcinoma 1,2 and are categorized in several classifications with subdivisions into three grades depending on the amount of atypical keratinocytes in the epidermis.
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