Expression of CD45RO on circulating CD19+ B-cells in Crohn's disease.

@article{Yacyshyn1993ExpressionOC,
  title={Expression of CD45RO on circulating CD19+ B-cells in Crohn's disease.},
  author={Bruce R. Yacyshyn and Linda M. Pilarski},
  journal={Gut},
  year={1993},
  volume={34 12},
  pages={1698-704}
}
Crohn's disease is an immunoregulatory disorder of the intestine that can be associated with systemic manifestations. This study analysed B-cell differentiation antigens to identify B-cell subpopulations unique to patients with Crohn's disease. CD45 isoform expression was used as an indicator of B-cell differentiation stage. This work shows that B-cells in blood and gut of patients with Crohn's disease are at an advanced stage of differentiation based on their unusual presentation of… CONTINUE READING