Expression of CD45RB and CD27 identifies subsets of CD4+ memory T cells with different capacities to induce B cell differentiation.

@article{Tortorella1995ExpressionOC,
  title={Expression of CD45RB and CD27 identifies subsets of CD4+ memory T cells with different capacities to induce B cell differentiation.},
  author={Carla Tortorella and Hendrik Schulze-Koops and Ranjeny Thomas and Judy B. Splawski and Laurie S. Davis and Louis J. Picker and Peter E Lipsky},
  journal={Journal of immunology},
  year={1995},
  volume={155 1},
  pages={149-62}
}
The capacity of four subsets of CD4+ memory T cells, defined by expression of CD45RB and CD27, to provide help for B cells was examined. Larger amounts of Ig were induced by CD45RBdimCD27- cells compared with the CD45RBdimCD27+ population, whereas CD45RBbrightCD27+ or CD27- cells were poor inducers of Ig synthesis. Mitomycin C treatment, which prevents suppressive activity, markedly enhanced Ig production supported by each subset except for CD45RBbrightCD27- cells. Mitomycin C-treated CD45RBdim… CONTINUE READING

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