Expression of CD44R1 adhesion molecule in colon carcinomas and metastases.

@article{Tanabe1993ExpressionOC,
  title={Expression of CD44R1 adhesion molecule in colon carcinomas and metastases.},
  author={Kenneth K Tanabe and Lee M. Ellis and Hideyuki Saya},
  journal={Lancet},
  year={1993},
  volume={341 8847},
  pages={725-6}
}
CD44 is a cell surface adhesion molecule postulated to control lymphocyte recirculation by facilitating entry into lymphoid tissue. Tumour cells transfected to overexpress the epithelial variant CD44R1 readily gain access to lymph nodes and distant metastatic sites in animal models, possibly by mimicking circulating lymphocytes. To investigate if human tumours display altered CD44 expression we performed reverse transcriptase a polymerase chain reaction (PCR) analysis of CD44 in 49 specimens… CONTINUE READING