Expression of CD44 3′-untranslated region regulates endogenous microRNA functions in tumorigenesis and angiogenesis

@inproceedings{Jeyapalan2011ExpressionOC,
  title={Expression of CD44 3′-untranslated region regulates endogenous microRNA functions in tumorigenesis and angiogenesis},
  author={Zina Jeyapalan and Zhaoqun Deng and Tatiana A. Shatseva and Ling Fang and Chengyan He and Burton B. Yang},
  booktitle={Nucleic acids research},
  year={2011}
}
The non-coding 3'-untranslated region (UTR) plays an important role in the regulation of microRNA (miRNA) functions, since it can bind and inactivate multiple miRNAs. Here, we show the 3'-UTR of CD44 is able to antagonize cytoplasmic miRNAs, and result in the increased translation of CD44 and downstream target mRNA, CDC42. A series of cell function assays in the human breast cancer cell line, MT-1, have shown that the CD44 3'-UTR inhibits proliferation, colony formation and tumor growth… CONTINUE READING
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