Expression of CD3, PD-L1 and CTLA-4 in mammary and extra-mammary Paget disease

@article{Karpathiou2018ExpressionOC,
  title={Expression of CD3, PD-L1 and CTLA-4 in mammary and extra-mammary Paget disease},
  author={Georgia Karpathiou and C{\'e}line Chauleur and Sirine Hathroubi and Cyril Habougit and Michel P{\'e}oc'h},
  journal={Cancer Immunology, Immunotherapy},
  year={2018},
  volume={67},
  pages={1297-1303}
}
BackgroundMammary and extra-mammary Paget disease is a rare form of intra-epithelial glandular neoplasm which is characteristically recurrent and necessitates multiple excisions that have an important impact on morbidity. Local immuno-modulating treatments have been applied with promising results, but the local immune markers of Paget disease have not been studied.Aim of the studyTo investigate the local immune micro-environment of Paget disease.Materials and methodsSixty-four specimens from 41… CONTINUE READING
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