Expression of CD133 in SW620 colorectal cancer cells is modulated by the microenvironment.

@article{Yang2012ExpressionOC,
  title={Expression of CD133 in SW620 colorectal cancer cells is modulated by the microenvironment.},
  author={Zhili Yang and Zhigang Wang and Y Fan and Qi Zheng},
  journal={Oncology letters},
  year={2012},
  volume={4 1},
  pages={75-79}
}
The use of CD133 as a marker for identifying and isolating colon cancer stem cells (CSCs) is controversial. In particular, it is not clear whether the pattern of expression is influenced by the tumor microenvironment. We analysed the expression of CD133 in the SW620 colon cancer cell line, which produces subpopulations with different levels of CD133. CD133(neg) and CD133(hi) SW620 cells were isolated and compared in hanging drop spheroid cultures. The expression of CD133 was examined under… CONTINUE READING