Expression of CD133 correlates with differentiation of human colon cancer cells.

  title={Expression of CD133 correlates with differentiation of human colon cancer cells.},
  author={Hai-liang Feng and Yu-qin Liu and Lijuan Yang and Xiao-cui Bian and Zhen-li Yang and Bei Gu and Hong Zhang and Chun-Jing Wang and Xiao-Ling Su and Xiao-Mei Zhao},
  journal={Cancer biology & therapy},
  volume={9 3},
CD133 has been identified as a cancer stem cell marker in colon and several other cancers, but its function is still unknown. We examined the CD133 expression in 44 human cancer cell lines, and found five of the 8 positive lines were from colon cancer. The CD133 positive subpopulation of colon cancer cells showed more vigorous growth and lower differentiation. Induction of differentiation reduced the CD133-positive population. Knockdown of CD133 expression in colon cancer cells could not induce… CONTINUE READING


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