Expression of Brugmansia candida Hyoscyamine 6beta-Hydroxylase gene in Saccharomyces cerevisiae and its potential use as biocatalyst

@article{Cardillo2008ExpressionOB,
  title={Expression of Brugmansia candida Hyoscyamine 6beta-Hydroxylase gene in Saccharomyces cerevisiae and its potential use as biocatalyst},
  author={Alejandra Beatriz Cardillo and Juli{\'a}n Rodr{\'i}guez Talou and Ana Mar{\'i}a Giulietti},
  journal={Microbial Cell Factories},
  year={2008},
  volume={7},
  pages={17 - 17}
}
BACKGROUND Tropane alkaloids, mainly hyoscyamine and scopolamine, are widely used in medicine due to their anticholinergic activity. Scopolamine has a higher demand being the more valuable alkaloid due to its fewer side effects and higher physiological activity. Anisodamine (6beta-hydroxyhyoscyamine) is the intermediate in the conversion of hyoscyamine into scopolamine. Current studies report that this alkaloid is potentially applicable in medicine. The gene that codifies for Hyoscyamine 6-beta… CONTINUE READING

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