Expression of Bmi-1 in epidermis enhances cell survival by altering cell cycle regulatory protein expression and inhibiting apoptosis.

@article{Lee2008ExpressionOB,
  title={Expression of Bmi-1 in epidermis enhances cell survival by altering cell cycle regulatory protein expression and inhibiting apoptosis.},
  author={K Kyungae Lee and Gautam Adhikary and Sivaprakasam Balasubramanian and Ramamurthy Gopalakrishnan and Thomas McCormick and Goberdhan P Dimri and Richard L Eckert and Ellen A. Rorke},
  journal={The Journal of investigative dermatology},
  year={2008},
  volume={128 1},
  pages={9-17}
}
The polycomb group (PcG) genes are epigenetic suppressors of gene expression that play an important role in development. In this study, we examine the role of Bmi-1 (B-cell-specific Moloney murine leukemia virus integration site 1) as a regulator of human epidermal keratinocyte survival. We identify Bmi-1 mRNA and protein expression in epidermis and in cultured human keratinocytes. Bmi-1 is located in the nucleus in cultured keratinocytes, and in epidermis it is expressed in the basal and… CONTINUE READING

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