Corpus ID: 67769112

Expression of Bmi-1 and EZH2 in tissues adjacent to human epithelial ovarian cancer cells of orthotopic implantation in nude mice

  title={Expression of Bmi-1 and EZH2 in tissues adjacent to human epithelial ovarian cancer cells of orthotopic implantation in nude mice},
  author={Genhai and Zhu and Lan and Hong and Shengtan and Wang and Zhaoxin and Yang and Chun-ying and Chen and Shixuan},
Ovarian cancer treatments mainly include surgery and chemotherapy. Compared with patient with other types of ovarian malignant tumors, strict conditions are required in epithelial ovarian cancer patients to retain ovarian and reproductive function [1]. Most patients undergo a comprehensive staging surgery that causes permanent loss of ovarian function. Many cases of epithelial ovarian cancer are diagnosed at childbearing ages [2]. The loss of ovarian function leads to early menopause or… Expand
Expression of Bmi-1 and EZH2 in tissues adjacent to human epithelial ovarian cancer cells of orthotopic implantation in nude mice
Although these studies lack long-term follow-up results and risk assessments, they indicate that transplantExpression of Bmi-1 and EZH2 in tissues adjacent to human epithelial ovarian cancer cells of orthotopic implantation in nude mice indicates that transplanting freeze-thawed ovarian tissue to restore ovarian function is necessary. Expand


Safety assessment of ovarian cryopreservation and transplantation in nude mice bearing human epithelial ovarian cancer.
Negative expression of CK-7, CA125 and survivin can be treated as screening criteria for security of ovarian tissues for transplantation and both subcutaneous and orthotopic transplantation are safe. Expand
Immunohistochemical expression and prognostic relevance of Bmi-1, a stem cell factor, in epithelial ovarian cancer.
Ovarian cancer is the fourth most common cause of cancer-related death in women. Bmi-1 is a stem cell factor implicated in many human malignancies with poor outcome. Few published reports on theExpand
Hormone replacement therapy and prognosis in ovarian cancer patients
  • A. Hein, F. Thiel, +12 authors C. Rauh
  • Medicine
  • European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation
  • 2013
The hypothesis that ovarian cancer is a hormonally influenced tumor is supported, with HRT having a positive effect on overall survival, specifically in the subgroup of patients with optimal debulking and no correlation was seen in relation to progression-free survival. Expand
Searching for evidence of disease and malignant cell contamination in ovarian tissue stored from hematologic cancer patients.
Preoperative imaging prevented operations and storage of tissue with cancer and highly sensitive real-time RT-PCR was positive in one CML patient and, this alarming result avoided tissue transplantation. Expand
Present and Future Fertility Preservation Strategies for Female Cancer Patients
The reader should be able to demonstrate knowledge about fertility preservation when counseling appropriate female cancer patients, recall current clinical strategies to assist women cancer patients to try to maintain their fertility if they wish, and appraise future strategies as they develop. Expand
Outcome of fertility preserving surgery in early stage ovarian cancer.
Fertility preserving surgery can be considered a safe treatment strategy in patients with stage IA, G1 or G2 ovarian carcinoma without adjuvant chemotherapy, and neither distant metastases nor mortality were reported among patients. Expand
Reimplantation of cryopreserved ovarian tissue from patients with acute lymphoblastic leukemia is potentially unsafe.
By quantitative RT-PCR, ovarian contamination by malignant cells in acute as well as chronic leukemia is demonstrated, whereas histology fails to do so, and chemotherapy before ovarian cryopreservation does not exclude malignant contamination. Expand
Comparison of two kinds of orthotopic xenograft models for human ovarian cancer.
There are differences between the two orthotopic xenograft models established with human epithelial ovarian cancer solid tumor tissue slices and human ovarian carcinoma cell line OVCAR-3, which are more similar to human ovarian cancer. Expand
Ovarian tissue cryopreservation for fertility preservation in cancer patients: Successful establishment and feasibility of a multidisciplinary collaboration
Ovarian tissue cryopreservation protocols can be implemented at pediatric and adult institutions through multi-disciplinary collaboration and provides hope for preserving the ability to have biological offspring to patients facing gonadotoxic therapies for a variety of medical conditions. Expand
Epithelial ovarian cancer: A case report
An 82-year-old female with ovarian cancer presented with severe abdominal distension and breathing difficulty on May 15 and appeared to be in critical condition, and bevacizumab rapidly eliminated the patient's massive ascites and pleural effusion, and achieved an effect that was not possible with other treatments. Expand