Expression of Bcl-XL Restores Cell Survival, but Not Proliferation and Effector Differentiation, in Cd28-Deficient T Lymphocytes

@article{Dahl2000ExpressionOB,
  title={Expression of Bcl-XL Restores Cell Survival, but Not Proliferation and Effector Differentiation, in Cd28-Deficient T Lymphocytes},
  author={A M Dahl and Christoph Klein and Pietro G. Andres and Cheryl A London and Michael P. Lodge and Richard C. Mulligan and Abul K Abbas},
  journal={The Journal of Experimental Medicine},
  year={2000},
  volume={191},
  pages={2031 - 2038}
}
Lymphocytes deficient in the T cell costimulatory molecule CD28 exhibit defects in cell survival, clonal expansion, and differentiation into effector cells. It is known that CD28-mediated signaling results in the upregulation of the Bcl family member Bcl-X(L). To investigate the role that Bcl-X(L) plays in the various functions of CD28, we expressed Bcl-X(L) in CD28-deficient primary T lymphocytes using retrovirus-mediated gene transfer. T cells were activated in vitro and infected with Bcl-X(L… CONTINUE READING

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