Expression of Bcl-2 family proteins and associated clinicopathologic factors predict survival outcome in patients with oral squamous cell carcinoma.

@article{Camisasca2009ExpressionOB,
  title={Expression of Bcl-2 family proteins and associated clinicopathologic factors predict survival outcome in patients with oral squamous cell carcinoma.},
  author={Danielle Resende Camisasca and J{\'u}lia Honorato and Vagner Gonçalves Bernardo and Lic{\'i}nio Esmeraldo da Silva and Eliene Carvalho da Fonseca and Paulo Ant{\^o}nio Silvestre de Faria and Fernando Luiz Dias and Simone de Queiroz Chaves Lourenço},
  journal={Oral oncology},
  year={2009},
  volume={45 3},
  pages={
          225-33
        }
}
The aims of this study were to assess the expression levels of three proteins involved in apoptosis--Bcl-2, Bcl-X, and Bax--and evaluate their relationship with clinicopathologic features and survival in oral squamous cell carcinoma (OSCC). Immunohistochemistry was used to evaluate protein expression in 53 primary OSCCs treated by radical surgery with free margins at a single institution in 1999. Histologic specimens were graded and analyzed for perineural invasion, lymphocytic infiltrate, and… CONTINUE READING

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