Expression of Bcl-2, but not Bax, correlates with estrogen receptor status and tumor proliferation in invasive breast carcinoma.

@article{Yang1999ExpressionOB,
  title={Expression of Bcl-2, but not Bax, correlates with estrogen receptor status and tumor proliferation in invasive breast carcinoma.},
  author={Qifeng Yang and Takeo Sakurai and Xuefeng Jing and Hiroki Utsunomiya and Liang Shan and Yasushi Nakamura and Misa Nakamura and Shoji Oura and Takaomi Suzuma and Goro Yoshimura and Teiji Umemura and Yozo Kokawa and Kennichi Kakudo},
  journal={Pathology international},
  year={1999},
  volume={49 9},
  pages={775-80}
}
Bcl-2 and Bax have been demonstrated to be associated with apoptosis in breast carcinoma, and the ratio between Bax and Bcl-2 seems to be an important determinant of cellular sensitivity to induction of apoptosis. However, little information is available on the relationship between Bcl-2, Bax and the proliferative activity of breast carcinoma. The purpose of this study was to investigate the significance of apoptosis-related genes bcl-2 and Bax and their correlation with expression of p53… CONTINUE READING

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